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KMID : 0363220190570050265
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Korean Journal of Dermatology
2019 Volume.57 No. 5 p.265 ~ p.269
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Three Fibrotic Conditions Treated with 5% Topical Imiquimod Cream as an Antifibrotic Agent
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Cho Yeo-Rye
Kim Ho-Jin
Seo Jeong-Wan
Kim Tae-Hoon
Kim Ki-Ho
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Abstract
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Imiquimod, a toll-like receptor agonist, is a topical immunomodulator that induces the production of several cytokines including interferon-alpha, which shows antifibrotic properties. We hypothesized that the antifibrotic effect of imiquimod would soften fibrotic skin lesions. Therefore, we applied topical imiquimod with topical tacrolimus or systemic acitretin in patients with refractory lesions of myxedema, angiolymphoid hyperplasia, and generalized discoid lupus erythematosus and confirmed improvement in fibrotic lesions in these patients. Thus, we conclude that use of imiquimod improves fibrotic skin lesions. This report describes our experience with the treatment of this condition along with a review of the related literature.
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KEYWORD
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Fibrosis, Imiquimod, Myxedema, Angiolymphoid hyperplasia with eosinophilia, Discoid lupus erythematosus
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